Orbimed Advisors 13F annual report

Orbimed Advisors is an investment fund managing more than $4.99 trillion ran by Sven Borho. There are currently 108 companies in Mr. Borho’s portfolio. The largest investments include Sinovac Biotech and Biogen Inc, together worth $554 billion.

$4.99 trillion Assets Under Management (AUM)

As of 7th February 2024, Orbimed Advisors’s top holding is 2,718,735 shares of Sinovac Biotech currently worth over $340 billion and making up 6.8% of the portfolio value. Relative to the number of outstanding shares of Sinovac Biotech, Orbimed Advisors owns more than approximately 0.1% of the company. In addition, the fund holds 827,600 shares of Biogen Inc worth $214 billion, whose value fell 16.9% in the past six months. The third-largest holding is Eli Lilly & Co worth $213 billion and the next is Boston Scientific worth $191 billion, with 3,306,800 shares owned.

Currently, Orbimed Advisors's portfolio is worth at least $4.99 trillion. The total portfolio value may be much higher due to cash assets that are not publicly disclosed such as fixed income, real estate, or cash equivalents.

Careers at Orbimed Advisors

The Orbimed Advisors office and employees reside in New York, New York. According to the last 13-F report filed with the SEC, Sven Borho serves as the Member at Orbimed Advisors.

Recent trades

In the most recent 13F filing, Orbimed Advisors revealed that it had opened a new position in Eli Lilly & Co and bought 365,400 shares worth $213 billion.

The investment fund also strengthened its position in Biogen Inc by buying 603,000 additional shares. This makes their stake in Biogen Inc total 827,600 shares worth $214 billion. Biogen Inc dropped 21.6% in the past year.

On the other hand, there are companies that Orbimed Advisors is getting rid of from its portfolio. Orbimed Advisors closed its position in Bristol-Myers Squibb Co on 14th February 2024. It sold the previously owned 2,584,900 shares for $184 million. Sven Borho also disclosed a decreased stake in Boston Scientific by 0.2%. This leaves the value of the investment at $191 billion and 3,306,800 shares.

One of the largest hedge funds

The two most similar investment funds to Orbimed Advisors are Copeland Capital Management and Financial Counselors Inc. They manage $4.99 trillion and $5 trillion respectively.


Sven Borho investment strategy

Orbimed Advisors’s portfolio is diversified across 2 sectors. Currently, their heaviest sector is Health Care — making up 66.3% of the total portfolio value. The fund focuses on investments in the United States as 54.6% of the portfolio companies are based in the United States.

The majority of the companies in the fund’s portfolio are large-cap stocks. Stocks with a size of more than $10 billion in market cap make up 19% of the total holdings value. On the other hand, small-cap stocks make up only 7.4% of the portfolio. The average market cap of the portfolio companies is close to $29 billion.

The complete list of Orbimed Advisors trades based on 13F SEC filings

These positions were updated on February 14th based on the fund’s latest 13F filing. Quickly find out what the most recently closed or increased positions are.

Security Shares Owned Value Allocation
Sinovac Biotech Ltd.
No change
2,718,735
$340,000,000,000 6.81%
Biogen Inc
268.48%
827,600
$214,158,052,000 4.29%
Eli Lilly & Co
Opened
365,400
$212,998,968,000 4.27%
Boston Scientific Corp.
15.17%
3,306,800
$191,166,108,000 3.83%
Intuitive Surgical Inc
12.87%
499,000
$168,342,640,000 3.37%
Edgewise Therapeutics Inc
No change
14,567,176
$159,364,905,000 3.19%
Biomarin Pharmaceutical Inc.
8.50%
1,571,410
$151,515,352,000 3.03%
Rayzebio Inc
Opened
2,365,213
$147,045,292,000 2.95%
Enliven Therapeutics Inc
Opened
8,998,338
$124,536,998,000 2.49%
SpringWorks Therapeutics, Inc.
41.74%
3,219,359
$117,506,604,000 2.35%
Merck & Co Inc
Opened
1,055,000
$115,016,100,000 2.30%
Ionis Pharmaceuticals Inc
168.54%
2,064,797
$104,458,080,000 2.09%
Disc Medicine Inc
Opened
1,702,237
$98,321,209,000 1.97%
Gracell Biotechnologies Inc.
18.06%
9,308,726
$93,459,609,000 1.87%
Tenet Healthcare Corp.
90.33%
1,224,400
$92,527,908,000 1.85%
Evolent Health Inc
37.69%
2,746,532
$90,717,952,000 1.82%
United Therapeutics Corp
Opened
386,100
$84,899,529,000 1.70%
Xtant Med Hldgs Inc
No change
73,114,592
$82,619,489,000 1.65%
Stryker Corp.
36.42%
269,000
$80,554,740,000 1.61%
Scholar Rock Hldg Corp
535.53%
4,245,000
$79,806,000,000 1.60%
Thermo Fisher Scientific Inc.
28.88%
143,800
$76,327,602,000 1.53%
Verona Pharma Plc
33.66%
3,777,778
$75,102,227,000 1.50%
Vaxcyte, Inc.
60.62%
1,153,091
$72,414,115,000 1.45%
Theseus Pharmaceuticals Inc
3.94%
17,713,600
$71,740,080,000 1.44%
Vertex Pharmaceuticals, Inc.
53.05%
175,200
$71,287,128,000 1.43%
Neurocrine Biosciences, Inc.
42.08%
519,279
$68,420,201,000 1.37%
Sarepta Therapeutics Inc
24.06%
697,500
$67,259,925,000 1.35%
Elevance Health Inc
Opened
141,500
$66,725,740,000 1.34%
Third Harmonic Bio Inc
No change
5,779,071
$63,396,409,000 1.27%
Natera Inc
36.59%
954,481
$59,788,690,000 1.20%
Crinetics Pharmaceuticals In
47.84%
1,667,360
$59,324,669,000 1.19%
Apellis Pharmaceuticals Inc
Opened
922,200
$55,202,892,000 1.11%
R1 RCM Inc.
Opened
4,803,200
$50,769,824,000 1.02%
Ars Pharmaceuticals Inc
5.72%
9,240,887
$50,640,061,000 1.01%
Keros Therapeutics, Inc.
24.45%
1,268,734
$50,444,864,000 1.01%
Humana Inc.
68.48%
109,900
$50,313,319,000 1.01%
Terns Pharmaceuticals Inc
1.84%
7,619,135
$49,448,186,000 0.99%
Alpine Immune Sciences Inc
37.89%
2,535,245
$48,321,770,000 0.97%
SI-BONE Inc
31.93%
2,292,531
$48,120,226,000 0.96%
Prelude Therapeutics Inc
8.66%
10,909,256
$46,582,523,000 0.93%
ALX Oncology Holdings Inc.
7.80%
3,095,000
$46,084,550,000 0.92%
Neuropace Inc
0.21%
4,003,967
$41,280,900,000 0.83%
Iovance Biotherapeutics Inc
134.50%
4,707,458
$38,271,634,000 0.77%
Syndax Pharmaceuticals Inc
12.83%
1,749,000
$37,795,890,000 0.76%
Icon Plc
Opened
132,200
$37,421,854,000 0.75%
Unitedhealth Group Inc
73.80%
70,000
$36,852,900,000 0.74%
Ikena Oncology Inc
3.36%
15,588,131
$43,773,045,000 0.88%
AMGEN Inc.
Opened
127,300
$36,664,946,000 0.73%
Apogee Therapeutics Inc
Opened
1,277,901
$35,704,554,000 0.72%
Janux Therapeutics Inc
16.98%
3,317,927
$35,601,357,000 0.71%
Compass Therapeutics Inc
1.83%
22,362,850
$34,886,046,000 0.70%
scPharmaceuticals Inc
15.89%
5,559,528
$34,858,241,000 0.70%
Argenx Se
68.63%
84,600
$32,184,378,000 0.64%
Fusion Pharmaceuticals Inc.
3.16%
3,122,770
$30,009,820,000 0.60%
Acelyrin Inc
Opened
4,001,711
$29,852,764,000 0.60%
Neumora Therapeutics Inc.
Opened
1,500,000
$25,575,000,000 0.51%
Xenon Pharmaceuticals Inc
51.64%
550,000
$25,333,000,000 0.51%
Rhythm Pharmaceuticals Inc.
Opened
536,642
$24,669,433,000 0.49%
Repare Therapeutics Inc.
No change
3,322,488
$24,254,162,000 0.49%
AbCellera Biologics Inc.
No change
4,180,768
$23,872,185,000 0.48%
Vera Therapeutics Inc
Opened
1,518,115
$23,348,609,000 0.47%
Pmv Pharmaceuticals Inc
1.34%
6,475,291
$20,073,402,000 0.40%
Kinnate Biopharma Inc.
98.08%
8,009,729
$18,983,058,000 0.38%
TELA Bio, Inc.
6.34%
2,835,542
$18,771,288,000 0.38%
Aerovate Therapeutics Inc
4.79%
756,930
$17,129,326,000 0.34%
Invivyd Inc
21.68%
4,127,565
$16,262,606,000 0.33%
Immatics N.v
Opened
1,543,407
$16,252,076,000 0.33%
Adicet Bio Inc
11.75%
8,322,140
$15,728,845,000 0.32%
Alnylam Pharmaceuticals Inc
68.30%
79,400
$15,197,954,000 0.30%
Krystal Biotech Inc
Opened
103,700
$12,865,022,000 0.26%
Verastem Inc
Opened
1,529,115
$12,446,996,000 0.25%
Corvus Pharmaceuticals Inc
No change
6,943,654
$12,220,831,000 0.24%
Regeneron Pharmaceuticals, Inc.
Opened
13,500
$11,856,915,000 0.24%
Amicus Therapeutics Inc
Opened
806,000
$11,437,140,000 0.23%
Passage Bio Inc
13.35%
10,124,576
$10,225,822,000 0.20%
Heron Therapeutics Inc
427.92%
5,928,591
$10,078,605,000 0.20%
Arrowhead Pharmaceuticals In
Opened
319,651
$9,781,321,000 0.20%
Uniqure Nv
15.60%
1,347,900
$9,125,283,000 0.18%
Dexcom Inc
Opened
73,200
$9,083,388,000 0.18%
Apollomics Inc
Opened
8,565,456
$8,265,665,000 0.17%
Gilead Sciences, Inc.
Opened
100,000
$8,101,000,000 0.16%
Morphic Hldg Inc
Opened
273,400
$7,895,792,000 0.16%
Turnstone Biologics Corp
Opened
3,099,265
$7,887,629,000 0.16%
RAPT Therapeutics, Inc.
77.51%
281,413
$6,993,113,000 0.14%
InspireMD Inc
Opened
2,133,405
$5,994,868,000 0.12%
X4 Pharmaceuticals, Inc.
41.91%
7,133,515
$5,981,452,000 0.12%
Cullinan Oncology, LLC
14.51%
544,848
$5,552,001,000 0.11%
Oric Pharmaceuticals, Inc.
74.95%
522,968
$4,811,306,000 0.10%
Illumina Inc
Opened
30,300
$4,218,972,000 0.08%
Ambrx Biopharma Inc.
Opened
296,000
$4,215,040,000 0.08%
Nextcure Inc
No change
2,711,013
$3,090,555,000 0.06%
Celldex Therapeutics Inc.
Opened
58,800
$2,332,008,000 0.05%
Arcus Biosciences Inc
61.39%
117,000
$2,234,700,000 0.04%
10x Genomics, Inc.
Opened
39,800
$2,227,208,000 0.04%
Fate Therapeutics Inc
Opened
528,080
$1,975,019,000 0.04%
Kezar Life Sciences Inc
8.77%
1,927,000
$1,825,640,000 0.04%
Bolt Biotherapeutics Inc
99.86%
1,541,000
$1,725,920,000 0.03%
Ys Biopharma Co Ltd
Opened
3,236,311
$1,653,755,000 0.03%
Vigil Neuroscience Inc
9.17%
448,891
$1,517,252,000 0.03%
BiomX Inc
60.57%
4,517,589
$1,264,925,000 0.03%
Chemomab Therapeutics Ltd
13.07%
2,241,274
$1,143,050,000 0.02%
Geron Corp.
Opened
485,000
$1,023,350,000 0.02%
Vir Biotechnology Inc
Opened
101,000
$1,016,060,000 0.02%
Agios Pharmaceuticals Inc
Opened
45,000
$1,002,150,000 0.02%
Calcimedica Inc
Opened
297,380
$850,507,000 0.02%
Elevation Oncology Inc
Opened
1,500,000
$805,500,000 0.02%
Acutus Med Inc
No change
2,648,386
$534,709,000 0.01%
Singular Genomics Systems In
No change
540,697
$248,775,000 0.00%
Bristol-Myers Squibb Co.
Closed
2,584,900
$183,761,000
Pfizer Inc.
Closed
2,599,000
$113,732,000
Tricida Inc
Closed
10,280,947
$107,744,000
Seagen Inc
Closed
762,600
$104,347,000
Mirati Therapeutics Inc
Closed
1,418,892
$99,095,000
Abbvie Inc
Closed
600,000
$80,526,000
Edwards Lifesciences Corp
Closed
966,300
$79,845,000
Mersana Therapeutics Inc
Closed
9,011,437
$60,917,000
Arcutis Biotherapeutics Inc
Closed
2,800,000
$53,508,000
Guardant Health Inc
Closed
992,400
$53,421,000
Bellus Health Inc
Closed
4,634,900
$48,971,000
Aclaris Therapeutics Inc
Closed
2,758,434
$43,418,000
Progyny Inc
Closed
1,134,053
$42,028,000
Chinook Therapeutics, Inc.
Closed
2,029,300
$39,896,000
Vectivbio Hldg Ag
Closed
6,473,561
$38,841,000
Travere Therapeutics Inc
Closed
1,253,130
$30,877,000
Biohaven Pharmactl Hldg Co L
Closed
170,769
$25,815,000
89bio Inc
Closed
3,658,869
$21,185,000
Gh Research Plc
Closed
1,622,060
$18,848,000
Meiragtx Hldgs Plc
Closed
2,108,143
$17,729,000
Decibel Therapeutics Inc
Closed
4,945,192
$17,110,000
2seventy Bio Inc
Closed
1,041,300
$15,151,000
KalVista Pharmaceuticals Inc
Closed
1,042,000
$15,119,000
Verastem Inc
Closed
17,200,000
$14,620,000
Rxsight Inc
Closed
1,202,833
$14,434,000
Mirum Pharmaceuticals Inc
Closed
521,891
$10,965,000
Cincor Pharma Inc
Closed
314,202
$10,312,000
Imara Inc
Closed
4,386,568
$10,001,000
Gemini Therapeutics Inc
Closed
5,826,223
$9,555,000
Mereo BioPharma Group plc
Closed
10,605,522
$9,132,000
Ventyx Biosciences Inc
Closed
225,000
$7,855,000
Galecto Inc.
Closed
4,090,937
$7,732,000
EyePoint Pharmaceuticals Inc
Closed
970,860
$7,680,000
Pulmonx Corp
Closed
435,000
$7,247,000
Jounce Therapeutics Inc
Closed
2,928,900
$6,854,000
Spdr Ser Tr
Closed
76,400
$6,060,000
Synlogic Inc
Closed
6,029,995
$5,728,000
Cybin Inc
Closed
10,453,600
$5,082,000
Applied Therapeutics, Inc.
Closed
4,250,000
$3,953,000
Graybug Vision, Inc.
Closed
4,163,347
$3,915,000
Achilles Therapeutics Plc
Closed
1,463,251
$3,307,000
Amneal Pharmaceuticals Inc
Closed
1,583,490
$3,199,000
Magenta Therapeutics Inc
Closed
2,250,953
$3,174,000
Burning Rock Biotech Ltd
Closed
1,282,816
$3,066,000
Harpoon Therapeutics, Inc.
Closed
3,025,908
$2,935,000
Dyne Therapeutics, Inc.
Closed
220,400
$2,799,000
Graphite Bio Inc
Closed
848,412
$2,689,000
Protara Therapeutics Inc
Closed
830,641
$2,459,000
LogicBio Therapeutics Inc
Closed
8,466,783
$2,307,000
Pyxis Oncology Inc
Closed
848,252
$1,671,000
Oncocyte Corporation
Closed
1,882,768
$1,374,000
Essa Pharma Inc
Closed
640,645
$1,166,000
Monte Rosa Therapeutics Inc
Closed
117,455
$960,000
Aeglea BioTherapeutics Inc
Closed
1,797,221
$945,000
Vor Biopharma Inc
Closed
111,808
$445,000
Longboard Pharmaceuticals In
Closed
113,500
$422,000
No transactions found
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